General Cell Based Assays
Eurofins Discoverx PathHunter Human IL-10 (IL10RA/IL10RB) Dimerization Cell-Based Assay Kit (U2OS)
The PathHunter Human IL-10 (IL10RA/IL10RB) Stable Cell Line Dimerization Assay (U2OS) measures ligand-induced dimerization of IL10RA/IL10RB. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx PathHunter eXpress LTB4R CHO-K1 β-Arrestin GPCR Assay, 10-Plate Kit. (93-0292E2CP0L)
The PathHunter LTB4R eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. leukotriene B4) based activation of LTB4R GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged LTB4R and EA-tagged β-Arrestin-2. Activation of LTB4R stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
ABclonal Technology CNR1 Rabbit pAb
This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene.
Eurofins Discoverx cAMP Hunter™ Rat DRD2L Cell-Based Assay Kit (CHO-K1)
The cAMP Hunter™ Rat DRD2L Gi Stable Cell Line Assay (CHO-K1) contains a stable clonal cell line used to measure DRD2L (GPCR) activity via decreased levels of intracellular cAMP. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Cayman Chemical EstradIol 17 DGlucuronIde 5mg
An estrogen metabolite that acts as a substrate of MRP2 (Km = 75 µM), and through MRP2-mediated transport, functions as a cholestatic agent, decreasing bile flow
Eurofins Discoverx HitHunter cGMP Assay, 2,400 dp (384-well). (90-0039M)
The HitHunter cGMP Assay is a detection kit offering a robust, sensitive and easy-to-use assay to measure intracellular cGMP levels. This product uses EFC technology, and contains ED-tagged cGMP, anti-cGMP antibody, and pure EA. Upon application to a cell which contains endogenous, untagged cGMP, the anti-cGMP antibody will be sequestered by binding to this untagged cGMP, allowing for EFC between the tagged cGMP and soluble EA. This will produce a proportional level of chemiluminescent signal. This kit may be used with Eurofins DiscoverX cell lines as well as cell lines from other sources. This detection kit contains reagents for 6 plates (384 well). For detailed product information, visit www.discoverx.com/products-applications/biochemical-assays.
Aat Bioquest Amplite™ Colorimetric Hypochlorite (Hypochlorous Acid) Assay Kit
Hypochlorite anion (ClO-) and its protonated form, hypochlorous acid (HClO) are critical reactive oxygen species (ROS) in biological systems.
Eurofins Discoverx PathHunter eXpress IGF1R Functional Assay, 10-Plate Kit. (93-0505E1CP17L)
The PathHunter eXpress IGF1R Functional Assay provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting RTKs. This kit assesses RTK activation via detection of activated IGF1R dimerization-induced SH2 domain protein recruitment. This product uses EFC technology. The included cell line overexpresses ProLink-tagged IGF1R and an EA-tagged SH2 domain protein. Upon ligand-induced receptor activation, SH2-EA recruitment leads to production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress DRD2S (Short Isoform) CHO-K1 β-Arrestin GPCR Assay, 10pl Kit. (93-0351E2CP0L)
The PathHunter DRD2S eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. dopamine) based activation of DRD2S GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged DRD2S and EA-tagged β-Arrestin-2. Activation of DRD2S stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress GHSR1a U2OS β-Arrestin-1 GPCR Assay, 2-Plate Kit. (93-0242E3CP5M)
The PathHunter GHSR1a (ARR1) eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. ghrelin) based activation of GHSR1a GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged GHSR1a and EA-tagged β-Arrestin-1. Activation of GHSR1a stimulates the recruitment of β-Arrestin-1 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress FGR Activity Assay, 10-Plate Kit. (93-0884E3CP16L)
The PathHunter eXpress FGR Activity Assay is a stable, engineered cell line for use in studying small molecule drug candidates targeting the FGR kinase domain. The cell line is engineered to express the catalytic domain from FGR fused to the cytokine receptor binding domain (CRBD) of JAK2. The cells co-express an Enzyme Acceptor (EA) tagged SH2 domain and a ProLink (PK) tagged Cytokine receptor. The CRBD is designed to bind the CTK catalytic domain to the GHR-PK. Activation of the GHR-PK induces receptor phosphorylation by the FGR catalytic domain. This leads to SH2-EA recruitment and production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress CCR7 HEK 293 β-Arrestin GPCR Assay, 10-Plate Kit. (93-0195E1CP0L)
The PathHunter CCR7 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. CCL19/MIP-3β) based activation of CCR7 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged CCR7 and EA-tagged β-Arrestin-2. Activation of CCR7 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter Human FGFR4 Functional Kinase Cell-Based Assay Kit (U2OS)
The PathHunter Human FGFR4 Stable Cell Line Functional Kinase Assay (U2OS) measures FGFR4 receptor tyrosine kinase activity via ligand-induced SH2 domain protein recruitment. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Hycult Biotech Inc LAL CHROMOGENIC ENDPOINT ASSAY
The LAL assays is to be used for the in vitro quantitative determination of bacterial endotoxin in various biological fluids (including sera), devices, (air)filters and tissue culture medium.
Electron Microscopy Sciences Flim Sleeve 135 mm/36 exp with Frosted Open Flap
Polyguard Polypropylene film sleeves are the finest archival quality material, and are guaranteed to give you ultimate protection for your most important film negatives. Polyguard is 100% acid free, as well as being free from optical distortion. It is resistant to water, grease, oil, alkalies, and organic solvents. Polyguard is durable, yet pliable and gentle to the film and will not become brittle, crack, or abrade the film.
Type: Frosted Open Flap